Title: Drugs causing fixed eruptions: a study of 450 cases

標(biāo)題：藥物性固定疹450例調(diào)查

BACKGROUND/背景：

1) Drug eruptions are among the most common cutaneous disorders encountered by the dermatologist.

藥物性皮疹是皮膚科醫(yī)師最常遇見的皮膚病癥。

2) Some drug eruptions, although trivial, may cause cosmetic embarrassment and fixed drug eruption (FDE) is one of them.

有些藥物性皮疹雖然不嚴(yán)重，但有損于面容，而固定疹(FDE)則是其中之一。

3) The diagnostic hallmark is its recurrence at previously affected sites.

診斷標(biāo)準(zhǔn)則是皮疹反復(fù)發(fā)生在同一部位。

OBJECTIVE: We evaluated 450 FDE patients to determine the causative drugs.

目標(biāo)：作者評價450例FDE患者以確定致病性藥物。

RESULTS/結(jié)果：

1) Cotrimoxazole was the most common causeof FDE.

復(fù)方新諾明是引起FDE 最常見的原因。

2)Other drugs incriminated were tetracycline, metamizole, phenylbutazone, paracetamol, acetylsalisylic acid, mefenamic acid, metronidazole, tinidazole, chlormezanone, amoxycillin, ampicillin, erythromycin, belladonna, griseofulvin, phenobarbitone, diclofenac sodium, indomethacin, ibuprofen, diflunisal, pyrantel pamoate, clindamycin, allopurinol, orphenadrine, and albendazole.

其他涉及的藥物有四環(huán)素、安乃近、保泰松、撲熱息痛、乙酰水楊酸、甲滅酸、滅滴靈、替硝唑、氯美扎酮、阿莫西林、紅霉素、顛茄、灰黃霉素、氨羊青霉素、苯巴比妥、雙氨酚酸鈉、消炎痛、布洛芬、雙氟尼酸、噻吩嘧啶、氯林可霉素、別嘌呤醇、鄰甲苯海拉明以及腸蟲清。

CONCLUSIONS/結(jié)論：

1) Cotrimoxazole was the most common cause of FDE, whereas FDE with diclofenac sodium, pyrantel pamoate, clindamycin, and albendazole were reported for the first time.

復(fù)方新諾明是引起FDE最常見的原因，而雙氯酚酸鈉、噻吩嘧啶、氯林可霉素、別嘌呤醇引起FDE則為首次報道。

2) FDE may have multiform presentations.

FDE表現(xiàn)形式多樣。

責(zé)任編輯：admin