Title: Simultaneous HPLC determination of multiple components in a commercial cosmetic cream

標(biāo)題：同步高效液相色譜(HPLC)測定日用美容霜中的多種成分

Content/內(nèi)容：

1) A high-performance liquid chromatographic method for the simultaneous determination of magnesium ascorbyl phosphate (I), imidazolidinylurea (II), a mixture of methyl-(III). ethyl-(IV), propyl-(V), butyl-( VI) parabens dissolved in phenoxyethanol, and ascorbyl palmitate (VII), was studied by using a cyano-propyl column and a methanol gradient at 220 and 240 nm.

利用氰丙基柱與在220~240 nm甲醇梯度條件下，應(yīng)用高效液相色譜(HPLC)同步測定抗壞血酸磷酸鎂(I)；咪唑烷基尿素(II)；一種溶解于苯氧乙醇的甲基-(皿)、乙基-(N)、丙基-(V)、丁基(V)的對羥苯甲酸混合物以及抗壞血酸棕櫚酸酯(VII)。

2) Calibration curves were found to be linear in the 0.055 mg ml (-1) range (compounds I, II, VII) and 0.9-160 mg ml(-1) (compounds III-VI).

在0.05~5 mg/ml(化合物I、II、VII)與0.9~160 mg/ml(化合物III~VI)范圍中，發(fā)現(xiàn)校正曲線成線性關(guān)系。

3) Linear regression analysis of the data demonstrates the efficacy of the method in terms of precision and accuracy.

數(shù)據(jù)線性回歸分析顯示該方法具有效的精確性與準(zhǔn)確性。

4) An extraction method is developed and validated in order to apply this chromatographic method to a commercial cosmetic cream.

已研制出有效萃取方法，以便把此色譜法應(yīng)用到日用美容霜中。

5) The precision of this method, calculated as the relative standard deviation (RSD) of the recoveries (1.57%-2.21%) was excellent for all compounds I-VII.

按照回復(fù)法的標(biāo)準(zhǔn)差(1.57%~2.21%)計算，此方法對于所有化合物(I~VII)均具有良好的精確性。

責(zé)任編輯：admin