Title:Tryptophan pyrolysis products, Trp-p-1 and Trp-P-2 induce apoptosis in primary cultured rat hepatocytes

標(biāo)題：色氨酸的熱解產(chǎn)物Trp-P-1與Trp-P-2誘導(dǎo)原代大鼠肝細(xì)胞細(xì)胞凋亡

Content/內(nèi)容：

1) The cytotoxicity of heterocyclic amines, dietary carcinogens derived from cooked foods, to primary cultured rat hepatocytes was studied.

本文研究烹飪食物中飲食致癌物稠雜環(huán)胺類對(duì)原代大鼠肝細(xì)胞的細(xì)胞毒性。

2) A tryptophan pyrolysis product, 3-amino-1, 4-dimethyl-5H-pyrido[4,3-b] indole(Trp-P-1) was the most cytotoxic of 11 compounds tested.

色氨酸熱解產(chǎn)物3-氨基-1，4-二甲基-5H-吡哆[4, 3-b]吲哚(Trp-P-1)在11種測(cè)試化合物中細(xì)胞毒性最強(qiáng)。

3) Trp-P-1 was found to induce apoptosis as measured by morphological changes in nuclear chromatin and internucleosomal DNA fragmentation.

發(fā)現(xiàn)Trp-P-1誘導(dǎo)細(xì)胞凋亡，表現(xiàn)為核染色質(zhì)與核小體間DNA分裂的形態(tài)學(xué)改變。

4) 3-Amino-1-methyl-5H-pyrido/ 4, 3-b/ indole(Trp-P-2) showed a moderate apoptotic effect, and other compounds had a similar but weaker effect.

3-氨基-1-甲基-5H-吡哆[4,3-b]吲哚(Trp-P-2)顯示中等細(xì)胞凋亡效應(yīng)，其他化合物效應(yīng)相似但較弱。

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